Ingxoxo yezenhlalo mayelana nokukhuluphala eSpain isishintshile ukugxila kwayo: ukudla kwendabuko kujoyinwe ... Imithi yokulahlekelwa isisindo njenge-semaglutide noma i-tirzepatideeziye zandisa intshisekelo yomtholampilo neyomphakathi. Njengoba ngaphezu kwesigamu sabantu abakhuluphele ngokweqile noma abakhuluphele, ngokusho kwe-INE (National Institute of Statistics), okubalulekile ukubhekana nalesi sifo njengenkinga engapheli futhi enezici eziningi, hhayi njengendaba yobuhle.
Ochwepheshe bayagcizelela ukuthi lezi zindlela zokwelapha aziyona inhlamvu yomlingo, kodwa ngamathuluzi okuthi, kuhlanganiswe nemikhuba enempilo, Basiza ukulawula isifiso sokudla futhi bathuthukise izinkingaEzenzweni zokwelashwa, imiphakathi yesayensi yaseSpain igqamisa ukuncipha kwesisindo esicishe sibe ngu-20% ezigulini ezithile kanye nomthelela omuhle ezingozini ze-cardiometabolic.
Ziyini lezi zidakamizwa futhi zisebenza kanjani?
Ama-agonists e-GLP-1 receptor (kanye ne-tirzepatide, i-agonist ekabili ye-GLP-1/GIP) ilawula indlala nokusutha, ukwandisa umuzwa wokusutha nokunciphisa isifiso sokudlaNgaphandle kwesifiso sokudla, zithonya izindlela ze-metabolic ezithinta i-glucose, isisindo, kanye nephrofayili ye-lipid.
Ucwaningo olwenziwa eNyuvesi yasePennsylvania, olwanyatheliswa kuyi-Nature Medicine, lunikeza izinkomba mayelana nesenzo salo ebuchosheni: esigulini esifundwe ngamasu e-intracranial, i-tirzepatide. Umsebenzi we-nucleus accumbens wehle okwesikhashanaindawo eyinhloko yesistimu yemivuzo exhunywe “nomsindo wokudla.” Umphumela wehla ngemva kwezinyanga, okuphakamisa ukuthi umthelela wokulawula umfutho ungase ukhawulelwe ngesikhathi.
Ababhali bacacisa ukuthi le mithi ayivunyelwe ukwelapha ukukhathazeka ngokudla noma ukuthatheka. Ngakho-ke, inkomba yayo kufanele ihambisane namashidi wedatha yezobuchwepheshe.Ukuhumusha kucacile: abonisa isithembiso, kodwa adinga ukulandelelwa kwezokwelapha kanye nohlelo oluphelele oluhlanganisa ukudla okunomsoco, ukuvivinya umzimba, nokusekelwa kokuziphatha.
Ukusebenza kahle kanye nobufakazi bomtholampilo bakamuva
E-Spain, ochwepheshe abavela ku-SEEDO basikhumbuza ukuthi izindlela zokwelapha ezintsha Bafinyelela ekunciphiseni isisindo cishe ngama-20% futhi bathuthukise izinkinga eziningiLo mphumela, obonwa ezivivinyweni nasekuzijwayezeni komtholampilo, uhumushela ezinzuzweni ezingaba khona zenhliziyo, i-metabolic kanye nekhwalithi yokuphila.
Mayelana nokuphepha kwe-pancreatic, abacwaningi be-Intermountain Health bethule ukuhlaziya kweziguli ezingama-346.667 lapho Akukho bungozi obukhulayo be-pancreatitis obubonwa kulabo abathole i-GLP-1 receptor agonists, kuhlanganise nalabo abane-hypertriglyceridemia enzima. Eqinisweni, ezigulini ezingenawo umlando we-pancreatitis, ukusetshenziswa kwale mithi kwakuhlotshaniswa nengozi ephansi ephindwe kane yokuyithuthukisa.
Odokotela baveza ukuthi lokhu okutholakele kusebenza kumaphrofayili ayinkimbinkimbi, njenge i-hypothyroidism, ngoba i-hypertriglyceridemia ivamise ukubambezela inqubo kadokotela ngenxa yokwesaba ukuphindela emuva. Ngobuhlakani kanye nokukhetha okufanele, idatha ivula umnyango wezinketho zokwelapha kubantu ababekhishwe ngaphambilini.
Ukuphepha nokubhekwa: impilo yengqondo neminye imiphumela
Ngesikhathi esifanayo, ingxoxo yomphakathi ihlanganisa nobufakazi obuvela ukukhathazeka, ukucindezeleka, noma izinguquko ezingokomzwelo Abanye abasebenzisi, okuhlanganisa nezibalo ezaziwayo, babike ukungaphatheki kahle okubukwayo noma izimpawu zemizwa ezihlobene nalezi zindlela zokwelapha. Ubufakazi abuphelele, kodwa abalawuli bakhuphule ukwengamela kwabo.
E-UK, i-MHRA ibuyekeza idatha yokuphepha futhi ikhuthaza ukubikwa kwemiphumela emibi engaba khona, kuyilapho ise-US. Kunomehluko ekulebheni izexwayiso zezengqondo uma kuqhathaniswa nezinye izindawo. Kunoma yikuphi, ochwepheshe batusa ukuqapha okuseduze, ukuxhumana nodokotela uma kuvela izimpawu eziyisixwayiso, nokugwema [okulandelayo]. ukuzelapha.
Njengoba amaqembu emitholampilo ahlanganisa le mithi ezinhlelweni ezihlelekile ebonisa, impumelelo yesikhathi eside idinga ukudla komuntu siquUkuzivocavoca okuguquliwe nokusekelwa kokuziphatha, ngaphezu kokuhlolwa komuntu ngamunye kwebhalansi yengozi yenzuzo.
Ukufinyelela nokusebenzisa ngendlela efanele eSpain
I-SEEDO ifune ukuthi ukufinyelela kulezi zindlela zokwelapha kube ngokulinganayo futhi kunganciki ezindleleni zezezimali. iphakamisa ukuxhaswa kwayo ngezimali ohlelweni lukahulumeni lapho kukhonjisiwe. Ngemuva kwenkulumo-mpikiswano kunenkinga yezempilo nezenhlalo: ukukhuluphala kuxhumene nezinkinga ezingaphezu kuka-200 futhi kunezindleko eziqondile ezigidini.
Ngokwemininingwane evela emphakathini uqobo, cishe u-40% wabantu ukhuluphele futhi u-15% ukhuluphele, izibalo Zinomthelela ekusetshenzisweni kokunakekelwa kwezempilo kanye nokukhiqiza.Ngasikhathi sinye, kunokukhathazeka mayelana nokwenza kancane: kunconywa ukugwema ukusetshenziswa ngenxa yezizathu zobuhle kanye nemiyalelo ngaphandle kwezinkomba.
Ochwepheshe bagcizelela ukubaluleka kokuqeqeshwa okuqhubekayo ukuze imithi ihambisane nephrofayili yesiguli ngasinye kanye nangaphakathi cabangela izici zezenhlalo nezomnotho lesi sifo. Umgomo ukubeka kuqala impilo nokunciphisa ukungalingani, hhayi ukudala ukufinyelela "okubili-speed".
Yini esemkhathizwe wezokwelapha
Ochwepheshe balindele igagasi lokuqamba okusha elinenqwaba yezinhlanganisela ekuthuthukisweni, Lokhu kuzonweba izinketho kodwa kudinga indlela yokusebenzisa ecacileNjengoba kuvela ama-molecule amasha, kuzoba ukhiye wokugcina ukuhlolwa okuqinile kokusebenza kahle, ukuphepha, kanye nokusebenza kahle kwezindleko kuzilungiselelo zaseYurophu.
Umuzwa ohlanganyelwe emkhakheni wezokwelapha ukuthi lezi zindlela zokwelapha ziguqule imithetho yomdlalo. inqobo nje uma zihambisana nendlela ebanzi kanye nokufinyelela okulungileLokho kulinganisela kuwukhiye wempumelelo enkulu ekulweni nokukhuluphala emphakathini wethu.
Ukuthuthukiswa kwemithi yokunciphisa isisindo kusekelwe ezindleleni eziqinile ze-neuroendocrine, imiphumela ephawulekayo yomtholampilo, nokuqapha okusebenzayo kokuphepha; indima yabo eSpain izoncika kokubili ukufinyelela okulinganayo kanye nokusetshenziswa ngendlela efanele kanye nokuhlanganiswa kwazo ezinhlelweni zezempilo ezibeka isiguli esikhungweni.
